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KMID : 0386819920020010037
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Journal of the Institute of Health Environmental Sciences
1992 Volume.2 No. 1 p.37 ~ p.52
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Benefits of Fermented Milk in Rats Fed by Hypercholesterolemic Diet
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Abstract
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This study was performed to investigate the long term effect of fermented milk in drink in rats fed by hypercholesterolemic diet for 12 months. In order to attain the object, 150 of 3-week-old male rats of Sprague-Dawley strain were divided into
six
groups according to diet and content content of fermented milk in drink.
This first group served as normal control group fed by standard diet. The second, cholesterol control group, was treated with standard diet containing 1% of cholesterol and 500.000IU/kg of vitamin D2, The other four groups, fermented mild groups,
FM-25,
FM-50, FM-75 and FM-100 were treated with standard diet containing 1% of cholesterol and 500,000IU/kg of vitamin D2 and supplied simultaneously with 25%, 50%, 75% and 100% of fermented milk in drink, respectively. The animals were sacrificed for
analysis in 3, 6, 9 and 12 months.
@ES The results were as follows;
@EN 1. Rats in all groups treated with cholesterol and vitamin D2 showed significantly lower food intake than did that of normal control (P<0.05). The drink consumption of fermented milk groups were significantly higher than those of normal
control
and
cholesterol control groups (p<0.05).
2. Rata in all groups treated with cholesterol and vitamin D2 lost weight in 6 months. The body weight of rats in fermented milk groups increased after 6 months while all the rats in the cholesterol control group died. The more percentage of
fermented
milk in drink increased, the more they gained weight.
3. Food and protein efficiency ratios of each group showed a tendency similar to that of body weight change. The ratios in fermented milk groups increased in 12 months while that became blunted in normal control group.
4. The relative weights of liver, kidney, heart, spleen, and adrenal gland in cholesterol group were higher than those in normal control group (p<0.05). No tendency of the relative organ weight among fermented milk groups and feeding periods was
observed.
5. The content of calcium in serum by feeding period significantly decreased in all groups(p<0.05). In case of the content of inorganic phosphorous in serum, no significant difference among groups or feeding periods was observed though that was
the
highest in the cholesterol control group.
6. The fermented milk groups showed significantly lower total cholesterol than did the cholesterol control group (p<0.05). The more percentage of fermented milk in drink increased, the lower the content got. The ratio of HDL-cholesterol total
cholesterol in fermented milk groups was significantly higher than that in cholesterol control group though it showed a tendency of decreasing by feeding periods. No tendency of content of serum protein and glucose among groups and feeding
periods
was
observed.
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KEYWORD
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